This Viewpoint details the development and regulatory path of aducanumab, a human IgG1 monoclonal antibody to treat Alzheimer disease. More
As the Covid-19 pandemic continues, using existing antibiotics appropriately and finding new ones has never been more urgent. More
Drs Allen and deSouza present the case of a middle-aged man with palpitations and chest pain in the setting of supraventricular tachycardia (SVT). The symptoms resolved when the tachycardia stopped, but a troponin test ordered as part of the initial workup returned elevated results. More
In a recent piece in the BMJ, Shannon Brownlee and Deborah Korenstein argue that if we want to move the needle overuse, we have to make overuse an issue of preventable harm, not just waste. More
The U.S. must strengthen primary care, the platform on which achieving better, more equitable, and more affordable care depends. More
This cohort study assesses strategies to triage patients for mammogram cancer screening during times of reduced capacity. More
The catchall term plays into a cultural notion that estrogen is what makes a woman a woman. More
Two-thirds of people living with serious illnesses aren't getting a therapy that could benefit them in many ways: palliative care. More
On the Race to Value podcast, Vikas Saini and Shannon Brownlee discuss Dr. Lown's legacy, trust as high-value care, hospital coordination, and much more. More
This cross-sectional study of discharge data from a national database of US hospitals examines the association of profits hospitals received from cesarean procedures and rates of cesarean delivery. More
Researchers at the University of Buffalo also found an increase in deaths related to falls. More
This cross-sectional study evaluates the appropriateness of antimicrobial use for hospitalized patients treated for community-acquired pneumonia or a urinary tract infection present at admission or for patients who had received fluoroquinolone or intravenous vancomycin treatment. More
Nearly all women who deliver babies through cesarean section at Columbia University Irving Medical Center in New York City receive injections of the blood thinner heparin for weeks after the procedure, to prevent potentially life-threatening blood clots. More
Uterine artery embolization (UAE) is used far less commonly than hysterectomy in the management of postpartum haemorrhage. More
Millions of colonoscopies, mammograms, lung scans, Pap tests and other cancer screenings were suspended for several months last spring in the United States and elsewhere as COVID-19 swamped medical care. Now researchers are studying the impact, looking to see how many cancers were missed and whether tumors found since then are more advanced. More
The numbers of people wearing these monitors are soaring as prices have fallen and device-makers promote them to doctors and patients. More
To reduce the incidence, morbidity, and mortality associated with breast cancer, accessible and affordable screening, diagnosis, treatment, and surveillance strategies that balance harms and benefits are needed. More
"We should work toward improving care for our patients with right-sized antibiotic courses." More
The USPSTF's expanded screening guidelines bring up important questions of screening harms and benefits, generalizing clinical trial results, and the impact of screening on health disparities. More